5-Amino-1MQ
5-Amino-1MQ (methylquinolinium NNMT-inhibitor reference compound, iodide salt) · ≥98% (HPLC)
5-Amino-1MQ is a small-molecule methylquinolinium derivative supplied as a characterized reference material for in-vitro studies of nicotinamide N-methyltransferase (NNMT) inhibition. Research Use Only.
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Research profile & documentation
- Why researchers study it
- Studied in vitro as a small-molecule tool compound for selectively inhibiting nicotinamide N-methyltransferase (NNMT) activity in cellular methylation and NAD⁺-salvage pathway research.
- Mechanism themes in research
- Selective NNMT enzyme inhibition in cell-based assaysCellular methylation-capacity and 1-methylnicotinamide product studiesNAD⁺-salvage pathway crosstalk researchSmall-molecule structure-activity characterization
- What the evidence does not establish
- Published references are in-vitro or pre-clinical and describe research context only. They do not establish safety, efficacy, or any outcome in humans or animals, and Get Peptides makes no such claims.
- Quality markers
- ≥98% (HPLC)MS identityLot COACold-chain
- What ships
- The sealed lot-controlled vial, a measured ampoule of bacteriostatic water, and a printed handling & reconstitution card — plus the per-lot COA. Everything to prepare it, in one box.
5-Amino-1MQ is a small-molecule methylquinolinium reference compound used in laboratory studies of nicotinamide N-methyltransferase, methylation capacity, and NAD⁺-salvage pathway biology. It is not a peptide, and this page focuses on compound identity, assay design, and evidence limits for in-vitro research.
Small-molecule identity
Unlike the peptide materials in much of the Helix catalog, 5-Amino-1MQ is a small-molecule methylquinolinium iodide reference compound. The catalog record describes it as C₁₀H₁₁IN₂ with CAS 42464-96-0. A researcher should verify salt form, molecular weight convention, purity, and lot identity against the COA before preparing standards or comparing results between suppliers.
NNMT as a research target
Nicotinamide N-methyltransferase transfers a methyl group from S-adenosyl-L-methionine to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine. In laboratory research, an NNMT inhibitor tool compound can help investigators test how methyl-donor use, nicotinamide clearance, and methylation balance interact with cellular metabolism. Enzyme selectivity must be established in the actual assay rather than assumed from a product label.
| Full name | 5-Amino-1MQ (methylquinolinium NNMT-inhibitor reference compound, iodide salt) |
| Research theme | Metabolic signaling |
| CAS number | 42464-96-0 |
| Molecular formula | C₁₀H₁₁IN₂ |
| Molecular weight | 286.11 g/mol |
| Purity | ≥98% (HPLC) |
| Physical form | Lyophilized powder |
| Storage | −20 °C, desiccated, protected from light |
Sequence
Reported research areas
- Nicotinamide N-methyltransferase (NNMT) enzyme-inhibition assays
- Cellular methylation and NAD⁺-salvage pathway research
- Small-molecule structure-activity characterization
- Analytical reference standard for identity and purity (HPLC/MS)
Credible sources
COA with every lot
Each 5-Amino-1MQ lot is characterized by reversed-phase HPLC for purity and by mass spectrometry for identity, then documented in a per-lot Certificate of Analysis. Unique lot numbers tie the vial back to its synthesis batch and analytical data.
- RP-HPLC purity result (≥98% (HPLC))
- Mass-spectrometry identity confirmation
- Appearance, molecular weight, and storage
- Lot number and testing status
Specimen Certificate of Analysis
| Product | 5-Amino-1MQ (reference) |
| Lot | HXR-2406-112 |
| Purity (RP-HPLC) | 98%+ |
| Identity (MS) | Confirmed · 286.11 g/mol |
| Appearance | Lyophilized powder |
| Storage | −20 °C, desiccated |
Representative document. Each lot has its own COA — these are quality documents, not medical claims.
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