AOD9604 is a synthetic 16-residue fragment related to the C-terminal region of human growth hormone. It is supplied as a characterized reference material for in-vitro peptide chemistry, fragment structure–activity work, and lipid-metabolism research. The page is intentionally framed around laboratory evidence and does not provide human-use or dosing guidance.
Identity and fragment design
AOD9604 is commonly described as a modified human growth-hormone fragment corresponding to residues 176–191, with a disulfide-constrained sequence and a reported molecular weight near 1815.1 g/mol. Public records list CAS 221231-10-3 and a molecular formula of C₇₈H₁₂₃N₂₃O₂₃S₂. Researchers should reconcile catalog data with the lot-specific COA, especially when comparing salts, sequence conventions, or analytical reporting formats.
Why fragments are useful
Peptide fragments can help investigators study one structural region without attributing every observation to the full parent protein. AOD9604 is therefore relevant to experiments that separate C-terminal fragment behavior from growth-hormone-receptor and IGF-axis signaling. This is a research design question: the value of a fragment depends on the assay, controls, purity, and whether the experiment can distinguish direct activity from degradation or matrix effects.
Analytical and assay context
Typical research questions include HPLC and mass-spectrometry identity confirmation, disulfide stability, peptide degradation, comparative fragment chemistry, and cell-free or cell-based lipid-metabolism pathway assays. Any result should be reported with the model system, material form, lot, purity method, and relevant negative or vehicle controls. In-vitro pathway observations should not be rewritten as clinical outcomes.
Research safety
Handle AOD9604 as a laboratory reference material under the institution’s chemical and biological safety procedures. Review the SDS and COA, use appropriate storage and waste controls, and document deviations from the supplier’s instructions. This material is Research Use Only and is not intended for human or veterinary use, diagnosis, or treatment.
Every AOD9604 order includes a sealed, lot-controlled vial, the completed lot documentation, and a handling & storage card. Product-specific handling follows the supplied documentation and institutional SOPs.
Evidence limits and research safety
Research findings can differ by model, assay, purity, formulation, and study design. Published cell, biochemical, and pre-clinical observations do not establish human or veterinary safety, efficacy, dosing, or suitability. Researchers should review the applicable SDS, institutional safety procedures, waste requirements, and lot-specific documentation before handling any reference material.
Related research
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Credible sources
- PubChem — AOD9604
- PubMed — AOD9604 and human growth-hormone fragment research
- PubMed — growth hormone residues 176–191